The 22nd district is based in Central New York and the Mohawk Valley, including Syracuse and Utica. It includes all of Onondaga, Oneida, and Madison Counties and a small sliver of Oswego County. The district was significantly altered by redistricting, losing all of its previous territory in the Southern Tier while adding Syracuse. The district has a PVI of D+1 and voted for Joe Biden by 8 points in 2020, similar to the partisanship of the old 24th district. The incumbent is Republican John Katko of the 24th district, who was elected with 53.1% of the vote in 2020.[2] Katko is retiring.